5‑Amino‑1MQ (short for 5‑Amino‑1‑methylquinolinium) is not a traditional peptide, despite how it’s sometimes labeled by suppliers. Instead, it’s a small‑molecule metabolic modulator that’s primarily studied as a potent inhibitor of nicotinamide N‑methyltransferase (NNMT) — an enzyme involved in cellular energy, fat storage, and NAD⁺ metabolism.
- Chemical nature: Small molecule (quinolinium derivative), not a long peptide chain.
- Primary target: NNMT enzyme, which methylates nicotinamide and can influence how cells store fat and use energy.
- Research status: Investigational compound intended for laboratory research only, not FDA‑approved for medical or dietary use.
Effects on Metabolic Pathways
Laboratory research suggests NNMT inhibition may:
- Enhance fat oxidation
- Improve glucose metabolism and insulin sensitivity
- Support mitochondrial efficiency
- Reduce adipose (fat) tissue expansion
These findings come mainly from cell studies and animal models, not human clinical trials.






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