Tirzepatide is a synthetic peptide therapeutic engineered to mimic and enhance the activity of the body’s natural incretin hormones. It’s best known as the active molecule in the FDA-approved drugs Mounjaro (for type 2 diabetes) and Zepbound (for chronic weight management), developed by Eli Lilly & Company.Â
Tirzepatide works through dual incretin receptor activation:
- GIP receptor agonism enhances insulin secretion and may improve fat metabolism and insulin sensitivity.
- GLP-1 receptor agonism boosts glucose-dependent insulin release, suppresses glucagon, delays gastric emptying, and increases satiety.
Together, these actions help regulate blood sugar and reduce appetite, contributing to improved metabolic control and weight loss.Â






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