Semax is a synthetic neuropeptide originally developed in Russia from a fragment of adrenocorticotropic hormone (ACTH 4–10). It’s engineered to be neuroprotective, nootropic, and neuromodulatory, supporting cognitive performance and brain resilience through multiple biological pathways.Â
Semax acts on the brain through multiple complementary mechanisms:
- Neurotrophic Factor Modulation
& Neuroplasticity: Semax enhances expression of brain-derived neurotrophic factor (BDNF) and other growth factors, which support neuron survival, synaptic plasticity, and long-term memory formation. Â - Neurotransmitter System Support: It modulates dopaminergic and serotonergic signaling, contributing to improved attention, motivation, executive function, and mood balance. Â
- Cerebrovascular & Cellular Protection: Semax exhibits antioxidant and anti-inflammatory effects and may enhance cerebral blood flow and cellular resilience under stress or ischemic conditions. Â
- Gene Expression & Cellular Health: The peptide influences gene networks tied to immune response, neuron survival, and vascular function, supporting recovery from injury and metabolic stress at a genomic level. Â






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