GHK-Cu (Copper Tripeptide-1) is a naturally occurring peptide-copper complex composed of the three amino acids glycine, histidine, and lysine bound to a copper (II) ion. This biologically active tripeptide has been widely studied in skin, tissue, and regenerative biology research for its role in cellular signaling, extracellular matrix modulation, and repair-related pathways. Â
GHK-Cu is recognized for its potential in studies related to:
- Tissue repair and remodeling — influencing gene expression linked to regenerative signaling and connective tissue maintenance. Â
- Collagen and extracellular matrix production — used in models exploring collagen, elastin, and glycosaminoglycan synthesis. Â
- Anti-inflammatory and antioxidant pathways — copper donation supports enzyme cofactors that enhance oxidative defense and may modulate inflammatory responses. Â





