SS-31 (also known as Elamipretide, MTP-131, or Bendavia) is a synthetic mitochondria-targeted tetrapeptide developed to explore mitochondrial bioenergetics, antioxidant defense, and cellular resilience in laboratory research settings. It’s used as a high-purity peptide tool for investigating mechanisms of mitochondrial dysfunction, oxidative stress, and energy metabolism in cell and animal models. Â
Mechanism of Action
- Mitochondrial Targeting: SS-31’s unique structure allows mitochondrial penetration and concentration at the inner membrane. Â
- Cardiolipin Binding: By directly interacting with cardiolipin, SS-31 helps maintain membrane integrity and supports respiratory chain complex stability. Â
- Oxidative Stress Reduction: It functions as a targeted antioxidant at the source of ROS generation, helping preserve ATP production and prevent oxidative damage. Â
- Bioenergetic Enhancement: Research shows SS-31 can improve mitochondrial respiration efficiency and ATP synthesis in models of dysfunction. Â







Reviews
There are no reviews yet.